منابع مشابه
Gut Flora in the Metabolism of Cyclamate
1. ["'C]Cyclamate was not metabolized when incubated with the liver, spleen, kidney or blood of rats or rabbits kept on a cyclamate-containing diet, and that had become converters of cyclamate into cyclohexylamine. 2. ["'C]Cyclamate was converted into cyclohexylamine when incubated under anaerobic conditions with the contents of the caecum, colon or rectum or with the faeces of cyclamate-pretre...
متن کاملThe fate of cyclamate in man and other species.
1. (14)C-labelled cyclamate has been administered to guinea pigs, rabbits, rats and humans. When given orally to these species on a cyclamate-free diet, cyclamate is excreted unchanged. In guinea pigs some 65% of a single dose is excreted in the urine and 30% in the faeces, the corresponding values for rats being 40 and 50%, for man, 30-50% and 40-60%, and for rabbits, 90 and 5%, the excretion ...
متن کاملConversion of cyclamate to cyclohexylamine in guinea pig.
Continuous oral administration of sodium cyclamate(CHS-Na) to guinea pig caused the gradual increase of urinary excretion of cyclohexylamine(CHA) after a certain period. The amount of CHA excreted was not only different in individuals, but also dependent on each experiment. It was diminished when CHS-Na was administered orally with antibiotics or intraperitoneally. It was shown from the incubat...
متن کاملSaccharin and cyclamate inhibit binding of epidermal growth factor.
The binding of 125I-labeled mouse epidermal growth factor (EGF) to 18 cell lines, including HeLa (human carcinoma), MDCK (dog kidney cells), HTC (rat hepatoma), K22 (rat liver), HF (human foreskin), GM17 (human skin fibroblasts), XP (human xeroderma pigmentosum fibroblasts), and 3T3-L1 (mouse fibroblasts), was inhibited by saccharin and cyclamate. The human cells were more sensitive to inhibiti...
متن کاملMetabolism of cyclamate and its conversion to cyclohexylamine.
Since cyclamates were first introduced in the early 1950s, arguments have raged over the potential carcinogenicity of this artificial sweetener. Concern over the safety of cyclamates arises from observations that some individuals and experimental animals can metabolize cyclamate to cyclohexylamine and that cyclohexylamine has been shown to produce testicular atrophy in experimental animals. Thi...
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ژورنال
عنوان ژورنال: Science
سال: 1970
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.168.3939.1605